The crystal structures of 4,6-dimethyltetrahydrobenzoangelicin (THBA), a furocoumarin analog, and of its furan-side cis–syn cycloadduct with thymine formed in the photoreaction with DNA, have been determined. The crystal structure of the latter compound contained only one enantiomeric form corresponding to the addition to a 5′-XpT site. Contrary to most psoralen derivatives studied, THBA showed higher photoreactivity toward synthetic oligonucleotides containing that sequence than toward those with the 5′-TpX sequence.
How to translate text using browser tools
1 July 2000
Photoaddition of 4,6-Dimethyltetrahydrobenzoangelicin to Thymine in DNA: X-ray Studies and Experiments with Model Oligonucleotides¶
Sergio Caffieri,
Giorgia Miolo,
Francesco Dall'Acqua,
Franco Benetollo,
Gabriella Bombieri
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
Photochemistry and Photobiology
Vol. 72 • No. 1
July 2000
Vol. 72 • No. 1
July 2000
